Spinning Disc Aerosol Generator SDAG

Biral is developing innovative particle generating technology for pharmaceutical formulation and production of inhaled drugs.

Pulmonary drug delivery is one of the fastest growing markets in the pharmaceutical industry. Recently, there has been increased interest in using the lung as a route for delivering systemic drugs. Certainly, it is an attractive alternative to delivery by injection for new biotechnology macromolecules.

Close control of particle size during production is essential for effective targeting of the right area of the lung. Too large a particle impacts the back of the throat; too small a particle gets exhaled. Typically, production involves conventional milling followed by a micronising process (fluid-energy milling). Unfortunately, this technique creates very broad particle size distributions. In fact particles may need selection to arrive at the correct narrow distribution - inherently wasteful of perhaps a very expensive drug.

Biral has developed a new technology, fundamentally extremely stable and capable of fine process-control. Indeed, it generates accurate micron-sized particles with a size distribution less than +/- 10%. Additionally, the technique is compatible with mass production.

We are now searching for potential strategic partners to develop this exciting technology from the initial prototypes into a product. If you are interested in learning more please contact Steve Evans.